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pentobarbital will reduce the extent or effect of buprenorphine buccal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital will lessen the level or outcome of ibuprofen by impacting hepatic enzyme CYP2C9/10 metabolism. Insignificant/Significance Unknown.pentobarbital will reduce the level or result of